The Effect of the Administration of Salam Leaf Ethanol Extract on IL-6 and IL-4 on Benzene-Induced Brain Networks of Rats

Benzene is poisonous to the human body and has been linked neuro-toxic neurodegenerative illnesses. Bay leaf extremely safe consume because it shown in experimental animals have no toxic, teratogenic, or genotoxic effects a strong antioxidant effect. The purpose of this study assess neuroprotective impact an ethanolic extract bay on rats exposed benzene. was divided into 11 groups: group 1 assigned control condition, groups 2 3 were negative controls, 4 5 positive 6-11 receive ethanol leaf. For 21 days, benzene injected intraperitoneally every three six days delivered orally. On day 22, sedated their brains collected examined for IL-4 IL-6 levels using Elisa kit 450 nm microplate reader. results indicated that increased statistically substantially given just (p0.05), whereas they decreased highest extract, 800 mg/kg BW. not significantly different from those normal (p>0.05). Thus, can be inferred leaves effect due presence flavonoids contribute prevention inflammation caused by exposure.